Immunoglobulin Sub-classes

Binding Site immunoglobulin and immunoglobulin subclass reagents provide specificity, sensitivity and the most up to date calibration to give users the greaTest degree of diagnostic confidence.

Key features of our immunoglobulins and immunoglobulin subclass assays:

• Specificity - Patented technology allows for the production of highly specific antisera ensuring reliable measurement of immunoglobulins and immunoglobulin subclasses.
• Sensitivity - Assays are optimized and where necessary utilize latex technology to ensure accurate results, even for deficient samples and samples at the low end of the pediatric normal range.
• Standardized* - Immunoglobulin assays are the only immunoglobulin assays calibrated to the most current standard, DA470K, to ensure accurate quantification.

Immunoglobulins

The quantification of serum immunoglobulins is a vital first-line Test in the investigation of Primary Immunodeficiency (PID). The results are often the basis for further investigative Testing such as immunoglobulin subclasses or vaccine response.

Selective IgA deficiency is the most common antibody deficiency. It can be defined as a serum IgA level of less than 0.07g/L (and normal IgG and IgM levels) in a patient older than 4 years.

The quantitation of IgD in serum samples is an important part in the diagnosis and monitoring of PID. Hyper-IgD syndrome has been described as a consideration in phagocyte deficiencies and IgD levels are also increased in periodic fever syndrome.

Binding Site provides automated solutions for the measurement of IgA, IgG and IgM on the Optilite analyser.

Optilite Subclass Assays